Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C;[alpha;-Methyl-L-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations

@article{Shoaf1998BrainSS,
  title={Brain Serotonin Synthesis Rates in Rhesus Monkeys Determined by [11C;[alpha;-Methyl-L-Tryptophan and Positron Emission Tomography Compared to CSF 5-Hydroxyindole-3-Acetic Acid Concentrations},
  author={Susan Elizabeth Shoaf and Richard Carson and Daniel Hommer and Wendol Williams and James Dee Higley and Bernard Schmall and Peter Herscovitch and William C. Eckelman and Markku Linnoila},
  journal={Neuropsychopharmacology},
  year={1998},
  volume={19},
  pages={345-353}
}
Twelve male, fasted, anesthetized rhesus monkeys were studied with positron emission tomography (PET) and [11C;[alpha;-methyl-L-tryptophan (αMTP) to determine serotonin synthesis rates as described by Diksic et al. (1991). It was expected that the serotonin synthesis rates determined for the whole brain would be correlated with CSF 5-hydroxyindole-3-acetic acid concentrations, a measure of central serotonin turnover, because both measures were obtained at steady state. However, no significant… CONTINUE READING