Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet

@article{Fernstrom1971BrainSC,
  title={Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet},
  author={John D. Fernstrom and Richard J. Wurtman},
  journal={Science},
  year={1971},
  volume={174},
  pages={1023 - 1025}
}
In the rat, the injection of insulin or the consumption of carbohydrate causes sequential increases in the concentrations of tryptophan in the plasma and the brain and of serotonin in the brain. Serotonin-containing neurons may thus participate in systems whereby the rat brain integrates information about the metabolic state in its relation to control of homeostatis and behavior. 
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688 Citations
Highly Influential Citations
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Background Citations
108
Methods Citations
4
Results Citations
2

688 Citations

Effects of long-term corn consumption on brain serotonin and the response to electric shock
Rats fed tryptophan-poor corn diets have reduced levels of brain serotonin and show increased responsiveness to electric shock. This diet-induced hyperalgesia can be reversed by feeding the animals…
Possible role of insulin in the transport of tyrosine and tryptophan from blood to brain
Differential effects of insulin on brain monoamine metabolism in rats.
The effect of a subconvulsive dose of insulin, which caused a 70% reduction of plasma glucose levels, on catecholamine and 5-hydroxytryptamine turnover in different brain regions of rats was…
Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats
Brain serotonin content: physiological regulation by plasma neutral amino acids.
TLDR
The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain.
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
TLDR
The main determinant of brain tryPTophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids that compete with it for uptake into the brain.
Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption
TLDR
The acceleration in brain serotonin synthesis produced by injecting rats with tryptophan or allowing them to consume a carbohydrate diet was not blocked by the prior elevation of brain serotonin levels or by a treatment that decreases impulse flow along serotoninergic neurons.
Possible role of insulin in the transport of tyrosine and tryptophan from blood to brain.
TLDR
The results suggest that insulin enhances the transport of tyrosine and tryptophan from blood to brain.
Dietary Carbohydrate Increases Brain Tryptophan and Decreases Free Plasma Tryptophan
TLDR
Car carbohydrate ingestion, which raises plasma tryptophan while depressing the concentrations of its competitors, increases the amount of tryPTophan in the brain and accelerates synthesis of serotonin in young rats; on the other hand, protein consumption causes proportionately greater increases in the other neutral amino acids than in plasma trypsophan, and thus fails to elevate brain tryptophon or serotonin.
Effects of the diet on brain function.
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References

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TLDR
Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan and plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrationis that occur nocturnally in untreated aninmals as result of their normal 24-hour rhythms.
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TLDR
Glucose, with and without exogenous insulin, was infused into normal males under conditions which produced a submaximal fall in total plasma FAA concentrations, revealing a significant decrease in the following essential amino acids; leucine, valine, threonine, isoleucines, phenyl-alanine and tyrosine.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
An attempt to combine ‘loading’ with the measurement of precursors, amines and metabolites in the 5-hydroxyindole pathway was described, to obtain a picture of the pathway in vivo under load.
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TLDR
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TLDR
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