Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction

  title={Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction},
  author={Hiroshi Matsuda and Hidekazu Kanetaka and Takashi Ohnishi and Takashi Asada and Etsuko Imabayashi and Seigo Nakano and Asako Katoh and Fumiko Tanaka},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
The aim of this study was to determine which brain structures show the greatest influence of partial volume effects (PVE) in single-photon emission tomography (SPET) studies on Alzheimer's disease (AD). Brain perfusion SPET was performed in 30 patients with probable AD and 62 age-matched healthy volunteers. SPET images were corrected for PVE using grey matter volume segmented from magnetic resonance images. The most prominent changes after PVE correction were observed in the medial temporal… CONTINUE READING


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Principles and methods

  • CD Frith, KJ Friston, J Ashburner
  • eds. Human brain function
  • 1997
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