Brain Rhythms Connect Impaired Inhibition to Altered Cognition in Schizophrenia

  title={Brain Rhythms Connect Impaired Inhibition to Altered Cognition in Schizophrenia},
  author={Benjamin R. Pittman-Polletta and Bern{\'a}t Kocsis and Sujith Vijayan and Miles A. Whittington and Nancy J Kopell},
  journal={Biological Psychiatry},
In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified by brain rhythms, can begin to bridge these levels of complexity. Oscillations in neuronal activity tie the pathophysiology of schizophrenia to alterations in local processing and… CONTINUE READING


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