Brain Reward Circuitry Insights from Unsensed Incentives

@article{Wise2002BrainRC,
  title={Brain Reward Circuitry Insights from Unsensed Incentives},
  author={Roy A Wise},
  journal={Neuron},
  year={2002},
  volume={36},
  pages={229-240}
}
  • R. Wise
  • Published 10 October 2002
  • Medicine, Psychology
  • Neuron
The natural incentives that shape behavior reach the central circuitry of motivation trans-synaptically, via the five senses, whereas the laboratory rewards of intracranial stimulation or drug injections activate reward circuitry directly, bypassing peripheral sensory pathways. The unsensed incentives of brain stimulation and intracranial drug injections thus give us tools to identify reward circuit elements within the associational portions of the CNS. Such studies have implicated the… 

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5
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References

SHOWING 1-10 OF 312 REFERENCES
Getting Formal with Dopamine and Reward
TLDR
Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards, and the optimal use of rewards in voluntary behavior would benefit from interactions between the signals.
Dopamine neurons and their role in reward mechanisms
  • W. Schultz
  • Psychology, Medicine
    Current Opinion in Neurobiology
  • 1997
TLDR
D dopamine neurons respond to appetitive events, such as primary rewards and reward-predicting stimuli, and correspond formally to concepts of behavioral and computational learning theories and may constitute teaching signals for appetitive learning.
Self-Stimulation of the Brain
TLDR
It is reasonable to hope that eventually it will be possible to control the reward systems pharmacologically in cases where behavior disorders seem to result from deficits or surfeits of positive motivation.
Cholinergic involvement in lateral hypothalamic rewarding brain stimulation
TLDR
In a conditioned place preference test, the rats preferred compartments in which they received carbachol, a cholinergic agonist, therefore seem critical for medial forebrain bundle (MFB) reward.
Neural Responses during Anticipation of a Primary Taste Reward
TLDR
The findings indicate that when rewards are predictable, brain regions recruited during expectation are, in part, dissociable from areas responding to reward receipt.
Localization of drug reward mechanisms by intracranial injections
TLDR
Five brain sites have been advanced as sites of rewarding opiate actions: the ventral tegmental area, nucleus accumbens septi, lateral hypothalamus, periaqueductal gray, and hippocampus; each of the clearly implicated sites is local to dopamine cell bodies or dopamine terminals that have been implicated in the rewarding effects of brain stimulation, food, and sex.
Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis.
TLDR
At the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine five-fold, thus amphetamine and cocaine increase dopamine in a behavior reinforcement system which is normally activated by eating.
Rewarding brain stimulation: role of tegmental cholinergic neurons that activate dopamine neurons.
TLDR
A mechanism for the involvement of Ch5 neurons in drug rewards and antimuscarinic psychosis is proposed and suggests that both acted through the same receptors near Ch5 cells.
The cost of delaying rewarding brain stimulation
Six rats trained to press a lever to obtain rewarding electrical stimulation of the brain through chronically implanted, lateral hypothalamic electrodes were used to estimate the rate at which short
A Neural Substrate of Prediction and Reward
TLDR
Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
...
1
2
3
4
5
...