Brain Norepinephrine: The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications

@inproceedings{AstonJones2007BrainNT,
  title={Brain Norepinephrine: The locus coeruleus and regulation of behavioral flexibility and attention: clinical implications},
  author={Gary Aston-Jones and Michiyo Iba and Edwin C. Clayton and Janusz Rajkowski and Jonathan D. Cohen},
  year={2007}
}
  • Gary Aston-Jones, Michiyo Iba, +2 authors Jonathan D. Cohen
  • Published 2007
  • Psychology
  • It has been proposed that the locus coeruleus (LC) regulates nonspecific arousal and thereby may participate in a wide range of functions. Our work indicates that, while the LC may indeed play an important role in arousal, it has more specific effects on behavior and may regulate cortical mechanisms involved in selective attention and task performance. In one study, we recorded impulse activity of LC neurons in monkeys performing a visual discrimination task. Phasic and tonic firing… CONTINUE READING

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