Brain N-acetylaspartate is reduced in Parkinson disease with dementia.

  title={Brain N-acetylaspartate is reduced in Parkinson disease with dementia.},
  author={H. Randall Griffith and Jan A den Hollander and Ozioma C. Okonkwo and Timothy O'Brien and Ray L. Watts and Daniel C. Marson},
  journal={Alzheimer disease and associated disorders},
  volume={22 1},
Persons with Parkinson disease (PD) are at risk of developing dementia. Of the dementias affecting patients with PD, PD with dementia (PDD) is not well understood, although brain imaging studies to date have observed characteristic patterns of brain atrophy. Metabolic differences have been observed in magnetic resonance spectroscopy (MRS) studies comparing patients with PDD to nondemented PD patients, although it is unclear whether PDD patients have abnormally low MRS ratios compared with… CONTINUE READING
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