Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.

@article{ODonnellLuria2017BrainMG,
  title={Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.},
  author={Anne H O'Donnell-Luria and Alexander Peter Lin and Sai K. Merugumala and Frances J Rohr and Susan E Waisbren and R Lynch and Vatche Tchekmedyian and Aaron D Goldberg and Andrew M. Bellinger and J Ricardo McFaline-Figueroa and Tracey G Simon and Esteban Gershanik and Bruce David Levy and David M. Cohen and Martin A. Samuels and Gerard Thomas Berry and Natasha Y Frank},
  journal={Molecular genetics and metabolism},
  year={2017},
  volume={121 1},
  pages={9-15}
}
Acute idiopathic hyperammonemia in an adult patient is a life-threatening condition often resulting in a rapid progression to irreversible cerebral edema and death. While ammonia-scavenging therapies lower blood ammonia levels, in comparison, clearance of waste nitrogen from the brain may be delayed. Therefore, we used magnetic resonance spectroscopy (MRS) to monitor cerebral glutamine levels, the major reservoir of ammonia, in a gastric bypass patient with hyperammonemic coma undergoing… CONTINUE READING