Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice

@article{Wu2016BrainIB,
  title={Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice},
  author={Xilin Wu and Li Liu and Ka-wai Cheung and Hui Wang and Xiaofan Lu and A K L Cheung and Wan Liu and Xiuyan Huang and Yanlei Li and Zhiwei Chen and Samantha Chen and Tong Zhang and Hao Wu},
  journal={Journal of Neuroimmune Pharmacology},
  year={2016},
  volume={11},
  pages={572-583}
}
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) is one of the common causes of cognitive dysfunction and morbidity among infected patients. However, to date, it remains unknown if a transmitted/founder (T/F) HIV-1 leads to neurological disorders during acute phase of infection. Since it is impossible to answer this question in humans, we studied NOD.Cg-Prkdc scid Il2rgtm1Wjl/SzJ mice (NSG) reconstituted with human PBMC (NSG-HuPBL), followed by the peritoneal… CONTINUE READING