Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

  title={Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions},
  author={Helgi B. Schi{\"o}th and Suzanne Craft and Samantha J Brooks and William H. Frey and Christian Benedict},
  booktitle={Molecular Neurobiology},
Insulin receptors in the brain are found in high densities in the hippocampus, a region that is fundamentally involved in the acquisition, consolidation, and recollection of new information. Using the intranasal method, which effectively bypasses the blood–brain barrier to deliver and target insulin directly from the nose to the brain, a series of experiments involving healthy humans has shown that increased central nervous system (CNS) insulin action enhances learning and memory processes… CONTINUE READING
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