Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

  title={Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease},
  author={P. Mandal and S. Saharan and M. Tripathi and G. Murari},
  journal={Biological Psychiatry},
  • P. Mandal, S. Saharan, +1 author G. Murari
  • Published 2015
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Extant data from in vivo animal models and postmortem studies indicate that Alzheimer's disease (AD) pathology is associated with reduction of the brain antioxidant glutathione (GSH), yet direct clinical evidence has been lacking. In this study, we investigated GSH modulation in the brain with AD and assessed the diagnostic potential of GSH estimation in hippocampi (HP) and frontal cortices (FC) as a biomarker for AD and its prodromal stage, mild cognitive impairment (MCI). METHODS… CONTINUE READING
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