Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity

@article{Cabou2008BrainGP,
  title={Brain Glucagon-Like Peptide-1 Regulates Arterial Blood Flow, Heart Rate, and Insulin Sensitivity},
  author={Cendrine Cabou and G{\'e}rard Campistron and Nicolas Marsollier and Corinne Leloup and C{\'e}line Cruciani-Guglielmacci and Luc P{\'e}nicaud and Daniel J Drucker and Christophe Magnan and Remy Burcelin},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2577 - 2587}
}
OBJECTIVE To ascertain the importance and mechanisms underlying the role of brain glucagon-like peptide (GLP)-1 in the control of metabolic and cardiovascular function. GLP-1 is a gut hormone secreted in response to oral glucose absorption that regulates glucose metabolism and cardiovascular function. GLP-1 is also produced in the brain, where its contribution to central regulation of metabolic and cardiovascular homeostasis remains incompletely understood. RESEARCH DESIGN AND METHODS Awake… CONTINUE READING