Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation

@inproceedings{Reno2017BrainGK,
  title={Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation},
  author={Candace M Reno and Erwin C. Puente and Zhenyu Sheng and Dorit Daphna-Iken and Adam J. Bree and Vanessa H. Routh and Barbara B. Kahn and Simon J Fisher},
  booktitle={Diabetes},
  year={2017}
}
GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis. However, the role of insulin-responsive GLUT4 in the central nervous system has not been well characterized. To assess its importance, a selective knockout of brain GLUT4 (BG4KO) was generated by crossing Nestin-Cre mice with GLUT4-floxed mice. BG4KO mice had a 99% reduction… CONTINUE READING