Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

  title={Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier},
  author={Svetlana M. Stamatovic and Richard F. Keep and Anuska V. Andjelkovic},
  booktitle={Current neuropharmacology},
The blood-brain barrier (BBB) is a highly specialized structural and biochemical barrier that regulates the entry of blood-borne molecules into brain, and preserves ionic homeostasis within the brain microenvironment. BBB properties are primarily determined by junctional complexes between the cerebral endothelial cells. These complexes are comprised of tight and adherens junctions. Such restrictive angioarchitecture at the BBB reduces paracellular diffusion, while minimal vesicle transport… CONTINUE READING
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