Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs

@article{Wong2013BrainDA,
  title={Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs},
  author={Yin Cheong Wong and Zhong Zuo},
  journal={Pharmaceutical Research},
  year={2013},
  volume={30},
  pages={2368-2384}
}
To elucidate the role of metabolism in the pharmacokinetics and pharmacodynamics of intranasal loxapine in conscious animals. At pre-determined time points after intranasal or oral loxapine administration, levels of loxapine, loxapine metabolites, and neurotransmitters in rat brain were quantified after catalepsy assessments (block test and paw test). Cataleptogenicity of loxapine was also compared with its metabolites. Intranasally administered loxapine was efficiently absorbed into systemic… CONTINUE READING
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