Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children

@article{Kaufman2006BrainDerivedNF,
  title={Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children},
  author={J. Kaufman and Bao-Zhu Yang and H. Douglas-Palumberi and Damion J Grasso and D. Lipschitz and S. Houshyar and J. Krystal and J. Gelernter},
  journal={Biological Psychiatry},
  year={2006},
  volume={59},
  pages={673-680}
}
BACKGROUND Child abuse and genotype interact to contribute to risk for depression in children. This study examined gene-by-gene and gene-by-environment interactions. METHODS The study included 196 children: 109 maltreated and 87 nonmaltreated comparison subjects. Measures of psychiatric symptomatology and social supports were obtained using standard research instruments, and serotonin transporter (5-HTTLPR) (locus SLC6A4) and brain-derived neurotrophic factor (BDNF) (variant val66met… Expand
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse
Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms.
Brain-derived neurotrophic factor and serotonin transporter gene-linked promoter region genes alter serum levels of brain-derived neurotrophic factor in humans.
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