Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus

@article{Hamaue2006BrainCA,
  title={Brain Catecholamine Alterations and Pathological Features with Aging in Parkinson Disease Model Rat Induced by Japanese Encephalitis Virus},
  author={Naoya Hamaue and Akihiko Ogata and Mutsuko Terado and Koyo Ohno and Senichiro Kikuchi and Hayato Sasaki and Kunio Tashiro and Masahiko Hirafuji and Masaru Minami},
  journal={Neurochemical Research},
  year={2006},
  volume={31},
  pages={1451-1455}
}
We analyzed two disease model groups with rats infected by Japanese encephalitis virus (JEV), a 90-day group and a 180-day group after JEV infection. The time measured by the modified pole test showed that motor activities in these two groups were slower than those of age-matched control groups. Striatal dopamine (DA) levels were significantly decreased in all JEV-infected rats. Norepinephrine concentration in brain regions in the 180-day group was significantly decreased in the medulla… CONTINUE READING

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