Brain Amyloid-β Plays an Initiating Role in the Pathophysiological Process of the PS1V97L-Tg Mouse Model of Alzheimer's Disease.

@article{Wang2016BrainAP,
  title={Brain Amyloid-β Plays an Initiating Role in the Pathophysiological Process of the PS1V97L-Tg Mouse Model of Alzheimer's Disease.},
  author={Wei Wang and Lu Lu and Qiao-Qi Wu and Jian-Ping Jia},
  journal={Journal of Alzheimer's disease : JAD},
  year={2016},
  volume={52 3},
  pages={1089-99}
}
Amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation are major pathophysiological events in Alzheimer's disease (AD). However, the relationships among these processes and which first exerts an effect are unknown. In the present study, we investigated age-dependent behavioral changes and the sequential pathological… CONTINUE READING