Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures

@article{Dadsetan2013BrainAF,
  title={Brain Alanine Formation as an Ammonia-Scavenging Pathway during Hyperammonemia: Effects of Glutamine Synthetase Inhibition in Rats and Astrocyte—Neuron Co-Cultures},
  author={Sherry Dadsetan and Eva Kukolj and Lasse K. Bak and Michael S{\o}rensen and Peter Ott and Hendrik Vilstrup and Arne Schousboe and Susanne Keiding and Helle S{\o}nderby Waagepetersen},
  journal={Journal of Cerebral Blood Flow & Metabolism},
  year={2013},
  volume={33},
  pages={1235 - 1241}
}
Hyperammonemia is a major etiological toxic factor in the development of hepatic encephalopathy. Brain ammonia detoxification occurs primarily in astrocytes by glutamine synthetase (GS), and it has been proposed that elevated glutamine levels during hyperammonemia lead to astrocyte swelling and cerebral edema. However, ammonia may also be detoxified by the concerted action of glutamate dehydrogenase (GDH) and alanine aminotransferase (ALAT) leading to trapping of ammonia in alanine, which in… CONTINUE READING

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