Brain‐derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord

@article{Slack2004BrainderivedNF,
  title={Brain‐derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord},
  author={Sarah E Slack and Sophie Pezet and Stephen B. McMahon and Stephen W. N. Thompson and Marzia Malcangio},
  journal={European Journal of Neuroscience},
  year={2004},
  volume={20}
}
Brain‐derived neurotrophic factor (BDNF) is involved in the modulation of synaptic transmission in the spinal cord, and several circumstantial lines of evidence suggest that it has the ability to modulate the activity of the NMDA receptor. Here we dissect the signalling mechanisms by which BDNF exerts its neuromodulatory role on the NMDA receptor subunit 1 (NR1). Using a preparation of adult isolated dorsal horn with dorsal roots attached, we found that electrical stimulation of roots induced a… 
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TLDR
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