Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs.

@article{Zhu2015BrahmaRT,
  title={Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs.},
  author={Ye Zhu and Dong Li and Yadong Wang and Chunli Pei and Song Liu and Lei Zhang and Zengqiang Yuan and Peng Zhang},
  journal={Cellular signalling},
  year={2015},
  volume={27 3},
  pages={606-13}
}
The Hippo signaling pathway restricts organ size by inactivating the Yorkie (Yki)/Yes-associated protein (YAP) family proteins. The oncogenic Yki/YAP transcriptional coactivator family promotes tissue growth by activating target gene transcription, but the regulation of Yki/YAP activation remains elusive. In mammalian cells, we identified Brg1, a major subunit of chromatin-remodeling SWI/SNF family proteins, which interacts with YAP. This finding led us to investigate the in vivo functional… CONTINUE READING

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