Bradykinin stimulates glutamate uptake via both B1R and B2R activation in a human retinal pigment epithelial cells.

@article{Lim2008BradykininSG,
  title={Bradykinin stimulates glutamate uptake via both B1R and B2R activation in a human retinal pigment epithelial cells.},
  author={Seul-ki Lim and Min-Jung Park and Ho-Kyoung Jung and Ah-Yeon Park and Dong-Il Kim and Jong-Chun Kim and Chun-Sik Bae and Kye-Yeop Kim and Kyoung-Chul Yoon and Ho Jae Han and Soo Hyun Park},
  journal={Life sciences},
  year={2008},
  volume={83 23-24},
  pages={761-70}
}
AIMS We were to examine the effect of bradykinin (BK) in the regulation of glutamate transporter and its related signaling molecules in a human retinal pigment epithelial (ARPE) cells, which are important cells to support retina. MAIN METHODS d-[2,3-(3)H]-aspartate uptake, western immunoblotting, reverse transcription polymerase chain reaction, [(3)H]-arachidonic acid release, and siRNA transfection techniques were used. KEY FINDINGS BK stimulated glutamate uptake as well as the mRNA… CONTINUE READING