Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass spectrometric structural characterisation and cloning of precursor cDNAs.

@article{Thompson2006BradykininrelatedPF,
  title={Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass spectrometric structural characterisation and cloning of precursor cDNAs.},
  author={Alan Hunter Thompson and Anthony John Bjourson and Chris Shaw and Stephen McClean},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2006},
  volume={20 24},
  pages={3780-8}
}
Amphibian skin secretions contain a plethora of bioactive compounds, many of which are understood to act to deter ingestion by predators. Bradykinins in particular are constitutively expressed in many amphibian skin secretions, mediating a variety of effects including hyperalgesia and contraction of gastric smooth muscle. Using a variety of proteomic techniques (high-performance liquid chromatography (HPLC) separation, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry… CONTINUE READING

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