Bradykinin receptors in cultured astrocytes from neonatal rat brain are linked to physiological responses.

@article{Gimpl1992BradykininRI,
  title={Bradykinin receptors in cultured astrocytes from neonatal rat brain are linked to physiological responses.},
  author={Gerald Gimpl and Wolfgang Walz and Carsten Ohlemeyer and Helmut Kettenmann},
  journal={Neuroscience letters},
  year={1992},
  volume={144 1-2},
  pages={139-42}
}
Specific binding sites for bradykinin (BK) have recently been demonstrated on astrocytes of primary cultures from neonatal rat brain. In this study we demonstrate that BK induces membrane currents in concert with an elevation of [Ca2+]i. In 67% of astrocytes, BK induced an inward current as determined with the perforated patch-clamp technique in the whole-cell recording configuration. In a small population of astrocytes (20%), a BK-activated outward current was observed, while in the remainder… CONTINUE READING

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