Bradykinin potentiation by ACE inhibitors: a matter of metabolism.

  title={Bradykinin potentiation by ACE inhibitors: a matter of metabolism.},
  author={Beril Tom and Andreas Dendorfer and Ren{\'e} de Vries and Pramod R. Saxena and Alexander H J Danser},
  journal={British journal of pharmacology},
  volume={137 2},
1. Studies in isolated cells overexpressing ACE and bradykinin type 2 (B(2)) receptors suggest that ACE inhibitors potentiate bradykinin by inhibiting B(2) receptor desensitization, via a mechanism involving protein kinase C (PKC) and phosphatases. Here we investigated, in intact porcine coronary arteries, endothelial ACE/B(2) receptor 'crosstalk' as well as bradykinin potentiation through neutral endopeptidase (NEP) inhibition. 2. NEP inhibition with phosphoramidon did not affect the… CONTINUE READING
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