Bradykinin is less potent in causing airway microvascular leakage in immature than in adult guinea-pigs. Role of neutral endopeptidase.

Abstract

To study the effect of maturation on bradykinin-induced airflow obstruction and airway microvascular leakage, we measured changes in both lung resistance (RL) and extravasation of Evans Blue dye in anaesthetized immature (aged 12 +/- 1 days) and adult guinea-pigs (aged 77 +/- 2 days). After measurement of RL after i.v. administration of bradykinin (2.5, 5… (More)

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@article{Yokoyama1993BradykininIL, title={Bradykinin is less potent in causing airway microvascular leakage in immature than in adult guinea-pigs. Role of neutral endopeptidase.}, author={Tomoaki Yokoyama and Katsuyuki Tokuyama and Asuka Morikawa and Takayoshi Kuroume}, journal={European journal of pharmacology}, year={1993}, volume={236 3}, pages={427-32} }