Bradykinin initiates cytokine-mediated inflammatory hyperalgesia.

  title={Bradykinin initiates cytokine-mediated inflammatory hyperalgesia.},
  author={S{\'e}rgio Henrique Ferreira and Berenice B Lorenzetti and Steve Poole},
  journal={British journal of pharmacology},
  volume={110 3},
1. The hyperalgesic activities in rats of bradykinin, carrageenin and lipopolysaccharide (LPS) were investigated in a model of mechanical hyperalgesia. 2. Bradykinin and carrageenin evoked dose-dependent hyperalgesia with maximum responses of similar magnitude to responses to LPS (1 and 5 micrograms). 3. Hoe 140, an antagonist of BK2 receptors, inhibited in a dose-dependent manner hyperalgesic responses to bradykinin, carrageenin and LPS (1 microgram) but not responses to LPS (5 micrograms… CONTINUE READING
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