Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear factor-kappaB.

Abstract

Bradykinin, a mediator of inflammation, is produced in the brain during trauma and stroke. It is thought to open the blood-brain barrier, although the mechanism is unclear. We have investigated, therefore, the effect of bradykinin on the expression of interleukin-6 (IL-6), a putative modulator of the blood-brain barrier, in astrocytes. IL-6 gene… (More)

Topics

  • Presentations referencing similar topics