Bradykinin induces formation of inositol phosphates and causes an increase in cytoplasmic Ca2+ in the osteoblastic cell line MC3T3-E1.

Abstract

Recordings of fura-2 fluorescence from single osteoblastic MC3T3-E1 cells showed that bradykinin (BK, 1 microM) induced a rapid increase in cytoplasmic free Ca2+ (Cai2+, from 114 +/- 13 to 239 +/- 17 nM, mean +/- SEM). Following this initial transient (less than 1 minute) increase there was a second slow increase in Cai2+ (from 117 +/- 11 to 151 +/- 12 nM… (More)

Topics

Cite this paper

@article{Ljunggren1991BradykininIF, title={Bradykinin induces formation of inositol phosphates and causes an increase in cytoplasmic Ca2+ in the osteoblastic cell line MC3T3-E1.}, author={Osten Ljunggren and H. Johansson and Sverker Ljunghall and Bertil B. Fredholm and Uri Lerner}, journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research}, year={1991}, volume={6 5}, pages={443-52} }