Bradykinin-induced preconditioning in patients undergoing coronary angioplasty.

  title={Bradykinin-induced preconditioning in patients undergoing coronary angioplasty.},
  author={Massoud A. Leesar and Marcus F. Stoddard and Srinivas Manchikalapudi and Roberto Bolli},
  journal={Journal of the American College of Cardiology},
  volume={34 3},
OBJECTIVES The purpose of this study was to determine whether administration of bradykinin reproduces the cardioprotective effects of ischemic preconditioning (PC) in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). BACKGROUND Experimental studies suggest that activation of the bradykinin B2 receptor is an important trigger of ischemic PC. However, it is unknown whether bradykinin can precondition human myocardium against ischemia in vivo. Multicenter clinical trials… CONTINUE READING
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Adenosine preconditions human myocardium against the metabolic effects of ischemia during PTCA (abstr)

  • M Leesar, Z Bhatti, R Masden, N Xenopoulos, R. Bolli
  • J Am Coll Cardiol 1997;29:316A
  • 1999
1 Excerpt

Adenosine preconditions against ischemia-induced systolic and diastolic dysfunction during percutaneous coronary angioplasty (abstr)

  • MF Stoddard, AMA Hasnie, M Leesar, R. Bolli
  • J Am Coll Cardiol 1998;31:458A
  • 1998
1 Excerpt

Letter to the Editor

  • R Bolli, M Leesar, M Ahmed, M Stoddard, J Broadbent
  • Circulation
  • 1998

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