Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors.

@article{Patwardhan2005BradykinininducedFC,
  title={Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors.},
  author={Amol M. Patwardhan and Kelly A. Berg and Armen N Akopain and Nathaniel A. Jeske and Nikita Gamper and William P Clarke and Kenneth M Hargreaves},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 39},
  pages={8825-32}
}
Peripheral opioid analgesia is increased substantially after inflammation. We evaluated the hypothesis that an inflammatory mediator, bradykinin (BK), evokes functional competence of the delta-opioid receptor (DOR) for inhibiting trigeminal ganglia (TG) sensory neurons. We also evaluated whether BK evokes trafficking of the DOR to the plasma membrane. Rat TG cultures were pretreated with BK (10 microm) or vehicle, and the effects of DOR agonists ([D-Pen2,5]-enkephalin or [D-Ala2, D-Leu5… CONTINUE READING