Bradykinin-induced bronchoconstriction in guinea pig in vivo: role of neural mechanisms.

@article{Ichinose1990BradykinininducedBI,
  title={Bradykinin-induced bronchoconstriction in guinea pig in vivo: role of neural mechanisms.},
  author={Makoto Ichinose and Maria G Belvisi and Peter J Barnes},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={253 2},
  pages={594-9}
}
The mechanism of bradykinin-induced bronchoconstriction was studied in anesthetized guinea pigs after both i.v. administration and direct airway instillation. We monitored airway opening pressure as an index of airway caliber, and the provocative dose of bradykinin required to produce 100% increase in airway opening pressure (PD100) was determined. Animals were pretreated with propranolol (1 mg/kg i.v.) to inhibit adrenergic bronchodilatation. After i.v. administration, the bronchoconstrictor… CONTINUE READING

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