Bradykinin-induced activation of phospholipase A2 is independent of the activation of polyphosphoinositide-hydrolyzing phospholipase C.

@article{Kaya1989BradykinininducedAO,
  title={Bradykinin-induced activation of phospholipase A2 is independent of the activation of polyphosphoinositide-hydrolyzing phospholipase C.},
  author={Hafize Kaya and George M Patton and Sungwoo Hong},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 9},
  pages={4972-7}
}
This study evaluates the role of phosphatidylinositol 4,5-bisphosphate (PIP2) and its metabolites as possible mediators in the activation of phospholipases A2 in porcine aortic endothelial cells. We compared the time courses of bradykinin-induced turnover of phosphoinositides and the appearance of unesterified arachidonic acid (uAA) and eicosanoids. The metabolism of phosphoinositides was examined in cells prelabeled with [3H]inositol, which has a similar distribution as the endogenous inositol… CONTINUE READING

Similar Papers

Loading similar papers…