Bradykinin increases the proportion of neonatal rat dorsal root ganglion neurons that respond to capsaicin and protons.

@article{Stucky1998BradykininIT,
  title={Bradykinin increases the proportion of neonatal rat dorsal root ganglion neurons that respond to capsaicin and protons.},
  author={Cheryl L Stucky and Lia G Abrahams and Virginia S Seybold},
  journal={Neuroscience},
  year={1998},
  volume={84 4},
  pages={1257-65}
}
A number of studies have examined bradykinin-induced sensitization of primary afferent neurons to mechanical or thermal stimuli. However, bradykinin-induced sensitization to other chemical stimuli has not been systematically addressed. We used primary cultures of dorsal root ganglion neurons from neonatal rats to determine whether bradykinin alters the responsiveness of individual neurons to capsaicin and protons. An increase in the concentration of free intracellular Ca2+ was used as a measure… CONTINUE READING

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