Bradykinin contracts the pupillary sphincter and evokes ocular inflammation through release of neuronal substance P.

@article{Bynke1983BradykininCT,
  title={Bradykinin contracts the pupillary sphincter and evokes ocular inflammation through release of neuronal substance P.},
  author={G. Bynke and Rolf H{\aa}kanson and J A H{\"o}rig and Stefan Leander},
  journal={European journal of pharmacology},
  year={1983},
  volume={91 4},
  pages={469-75}
}
Bradykinin contracts the isolated rabbit sphincter pupillae muscle. The contraction produced by 10(-8) M bradykinin was resistant to atropine but not to tetrodotoxin, suggesting a non-cholinergic nervous mechanism. The contraction was blocked by specific substance P (SP) antagonists, suggesting the involvement of SP. The SP antagonists tested were [D-Pro2,D-Trp7,9]SP-(1-11) and [Arg5,D-Trp7,9]SP-(5-11). The bradykinin-induced contraction exhibited marked tachyphylaxis in contrast to that… CONTINUE READING

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