Bradykinin antagonists: development and applications.

  title={Bradykinin antagonists: development and applications.},
  author={John M Stewart},
  volume={37 2},
Bradykinin (BK) is involved in regulation of every major physiological system and is an initiator or mediator of many pathophysiological conditions. Rapid progress in understanding these aspects of BK biology has come since the discovery of BK antagonists. This article reviews principal points in the history of the kallikrein-kinin field and of kinin biology. The chemistry and development of antagonists for B1 and B2 kinin receptors is discussed. Uses of the antagonists in biomedical research… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Therapeutic options directed against platelet activating factor, eicosanoids and bradykinin in sepsis.

The Journal of antimicrobial chemotherapy • 1998
View 8 Excerpts
Highly Influenced

Chimerism: a strategy to expand the utility and applications of peptides.

Methods in molecular biology • 2005
View 9 Excerpts
Highly Influenced

Solution conformations of bradykinin antagonists modified with Calpha-Calpha cyclized nonaromatic residues.

Journal of peptide science : an official publication of the European Peptide Society • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…