Bradykinin and serotonin effects on various types of cutaneous nerve fibres

@article{Beck1974BradykininAS,
  title={Bradykinin and serotonin effects on various types of cutaneous nerve fibres},
  author={Peter W. Beck and Hermann O. Handwerker},
  journal={Pfl{\"u}gers Archiv},
  year={1974},
  volume={347},
  pages={209-222}
}
  • Peter W. Beck, Hermann O. Handwerker
  • Published in Pflügers Archiv 1974
  • Chemistry, Medicine
  • Summary1.Bradykinin (BKN) and Serotonin (5-HT) are endogeneous substances yielded from injured tissue and evoke pain reactions in man and animals when brought into the skin even in small quantities. In order to test which nervous elements mediate the sensations evoked by these “local hormones” we studied the spike responses of single afferent fibres in cutaneous nerves of the cat's hind leg upon intraarterial administration of small doses (5–30 μg) of 5-HT and BKN.2.Thick myelinated, thin… CONTINUE READING

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    Depolarizing Effectors of Bradykinin Signaling in Nociceptor Excitation in Pain Perception

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    Caenorhabditis elegans nicotinic acetylcholine receptors are required for nociception

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