Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

@article{Chuang2001BradykininAN,
  title={Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition},
  author={Huai-hu Chuang and Elizabeth D. Prescott and Haeyoung Kong and Shannon D. Shields and Sven-Eric Jordt and Allan I. Basbaum and Moses V Chao and David Julius},
  journal={Nature},
  year={2001},
  volume={411},
  pages={957-962}
}
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to noxious stimuli. Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine kinase (TrkA) receptors, respectively, to stimulate phospholipase C (PLC) signalling pathways in primary afferent neurons. How these actions produce sensitization to physical or chemical stimuli has not been elucidated at the… CONTINUE READING
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