Bradykinin and inflammatory pain

@article{Dray1993BradykininAI,
  title={Bradykinin and inflammatory pain},
  author={Andy Dray and Martin N. Perkins},
  journal={Trends in Neurosciences},
  year={1993},
  volume={16},
  pages={99-104}
}

Figures from this paper

Bradykinin, Cytokines and Inflammatory Hyperalgesia

TLDR
Bradykinin and related peptides are produced at sites of tissue injury and inflammation and have an important role in mediating the responses of the tissues to damage and associated pain, notably when the hyperalgesia is secondary to an earlier inflammatory insult.

Kinins and their receptors in hyperalgesia.

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  • 1997
TLDR
The evidence for modulation of nociception and central pain generation is compelling, as central bradykinin administration causes hyperalgesia, whereas B2 antagonists are antinociceptive.

Kinin receptors in pain and inflammation.

Interactions between kinins and the inflammatory pain process

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A large number of variants on these two peptides have been identified, such as T kinin which is specific to the rat, and others in man but little is known about their role in the modulation of nociception.

B2 receptor-mediated enhanced bradykinin sensitivity of rat cutaneous C-fiber nociceptors during persistent inflammation.

TLDR
In chronically inflamed tissue, sensitivity of C-fiber nociceptors to BK, which is B2 receptor mediated, is strongly increased and B1 receptor may not be important to a persistent inflammatory state, at least at the primary afferent level.

Bradykinin Antagonists Have No Analgesic Effect on Incisional Pain

TLDR
None of the doses of either dALBK or HOE-140 affected the responses to punctate or blunt mechanical stimulation or heat, either as a pretreatment or as a posttreatment, which support the unique mechanisms for incision-induced pain relative to inflammation-related pain.

Pathogenesis and Mechanisms of Inflammation and Pain

TLDR
The severe pain that accompanies inflammatory disease such as rheumatoid arthritis is caused by the action of pain-producing substances such as kinins on nociceptor neurons sensitised by locally produced prostaglandins, and perhaps sympathomimetics released from sympathetic nerves.

Excitation and sensitization of nociceptors by bradykinin: what do we know?

TLDR
Prostaglandins sensitize bradykinin-induced excitation in normal tissues by restoring desensitized responses due to the inhibition of protein kinase A.
...

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