Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

@article{Zaika2011BradykininAI,
  title={Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.},
  author={Oleg Leonidovych Zaika and Mykola Mamenko and Roger G O'neil and Oleh Pochynyuk},
  journal={American journal of physiology. Renal physiology},
  year={2011},
  volume={300 5},
  pages={F1105-15}
}
Activation of the renal kallikrein-kinin system results in natriuresis and diuresis, suggesting its possible role in renal tubular sodium transport regulation. Here, we used patch-clamp electrophysiology to directly assess the effects of bradykinin (BK) on the epithelial Na(+) channel (ENaC) activity in freshly isolated split-opened murine aldosterone-sensitive distal nephrons (ASDNs). BK acutely inhibits ENaC activity by reducing channel open probability (P(o)) in a dose-dependent and… CONTINUE READING
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