Bradykinin BK2 receptors contribute to reflex cardiovascular responses during brief abdominal ischemia.

  title={Bradykinin BK2 receptors contribute to reflex cardiovascular responses during brief abdominal ischemia.},
  author={Premjit S Chahal and Stephen V. Rendig and John C. Longhurst},
  journal={The American journal of physiology},
  volume={274 1},
Ischemically sensitive visceral sympathetic nerve fibers, which are thought to represent the afferent limb of a strong cardiovascular pressor reflex, can be stimulated by exogenously applied bradykinin (BK). During ischemia, BK also is known to be produced locally and to serve as an endogenous stimulus for activation of ischemically sensitive nerve endings. It is unclear, however, whether ischemically induced BK production is sufficient to elicit a reflex cardiovascular response. Accordingly… 
Reflex cardiovascular response to brief abdominal visceral ischemia is mediated in part by prostaglandins.
Prostaglandin concentrations are elevated in intestinal lymph during brief abdominal visceral ischemia, and exogenously applied prostaglandins can directly stimulate or sensitize ischemically
Activation of visceral afferents by bradykinin and ischemia: independent roles of PKC and prostaglandins.
The results suggest that the contribution from PKC to the activation of ischemically sensitive C fibers, particularly by BK, does not require an intact cyclooxygenase system.
Responses of blood pressure and renal sympathetic nerve activity to colorectal distension in anesthetized rats.
It is suggested that noxious visceral stimulation at lower spinal levels reduces MAP by inhibiting sympathetic output in CNS-intact anesthetized rats and results in an increase in sympathetic-induced MAP in spinalized anesthenized rats.
Role of spinal NMDA and non-NMDA receptors in the pressor reflex response to abdominal ischemia.
The combined data suggest that spinal NMDA and AMPA receptors play a role in the abdominal ischemia pressor reflex.
ntestinal ischemia preconditions myocardium : role of protein kinase C and mitochondrial K channelATP
Evidence is provided that protein kinase C and mitochondrial K channel are involved in the ATP mechanism of the early preconditioning induced by intestinal ischemia, and that this mechanism involves the activation of protein Kinase C-mitochondrial K ATP channel signaling pathway in anesthetized rats.