Bradykinin B2, but not B1, receptor antagonism has a neuroprotective effect after brain injury.

@article{Goerlach2001BradykininBB,
  title={Bradykinin B2, but not B1, receptor antagonism has a neuroprotective effect after brain injury.},
  author={Christoph Goerlach and Tibor Hortob{\'a}gyi and Szabolcs Hortob{\'a}gyi and Zolt{\'a}n Beny{\'o} and Jane K. Relton and Eric T. Whalley and Michael R. Wahl},
  journal={Journal of neurotrauma},
  year={2001},
  volume={18 8},
  pages={833-8}
}
The aim of the present study was to measure the therapeutic effects of bradykinin antagonists on lesion volume and brain swelling induced by cold injury in the parietal cortex of rat and mouse, respectively. Cold lesion was induced by application of a precooled (-78 degrees C) copper cylinder (3 mm diameter) to the intact dura of rat and mouse for 6 and 30 sec, respectively. At 24 h after the injury, the brains were removed and lesion volume was determined by the triphenyltetrazolium chloride… CONTINUE READING
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