Bradykinin–evoked sensitization of airway sensory nerves: A mechanism for ACE–inhibitor cough

  title={Bradykinin–evoked sensitization of airway sensory nerves: A mechanism for ACE–inhibitor cough},
  author={A. Fox and U. Lalloo and M. Belvisi and M. Bernareggi and K. Chung and P. Barnes},
  journal={Nature Medicine},
  • A. Fox, U. Lalloo, +3 authors P. Barnes
  • Published 1996
  • Medicine
  • Nature Medicine
  • Cough accompanied by an increased sensitivity of the cough reflex is the most common symptom of inflammatory airway disease1,5. This symptom is also frequently reported in patients receiving angiotensin–converting enzyme (ACE) inhibitors as therapy for heart failure or hypertension2–4, although the underlying mechanism is unknown. We have investigated the possibility that the inflammatory peptide bradykinin, normally degraded by ACE, causes sensitization of airway sensory nerves and an… CONTINUE READING
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