Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin.

@article{Silva1949BradykininAH,
  title={Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin.},
  author={Maur{\'i}cio Rocha e Silva and Wilson T. Beraldo and G. Rosenfeld},
  journal={The American journal of physiology},
  year={1949},
  volume={156 2},
  pages={
          261-73
        }
}
I N THE course of experiments on the physiological action of the venom of Bothrope jararaca, we found that some blood samples taken from a dog after the injection of minute doses of the venom had a stimulating effect upon the isolated gut of the guinea pig. This was not due to direct action of the venom since the gut had been previously made refractory to it; no desensitization could be observed after several additions of the serum to the perfusing bath containing the piece of guinea pig ileum… CONTINUE READING

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