Bradykinetic alcohol dehydrogenases make yeast fitter for growth in the presence of allyl alcohol.

@article{Plapp2013BradykineticAD,
  title={Bradykinetic alcohol dehydrogenases make yeast fitter for growth in the presence of allyl alcohol.},
  author={Bryce V Plapp and Ann Ting-I Lee and Aditi Khanna and John M. Pryor},
  journal={Chemico-biological interactions},
  year={2013},
  volume={202 1-3},
  pages={104-10}
}
Previous studies showed that fitter yeast (Saccharomyces cerevisiae) that can grow by fermenting glucose in the presence of allyl alcohol, which is oxidized by alcohol dehydrogenase I (ADH1) to toxic acrolein, had mutations in the ADH1 gene that led to decreased ADH activity. These yeast may grow more slowly due to slower reduction of acetaldehyde and a higher NADH/NAD(+) ratio, which should decrease the oxidation of allyl alcohol. We determined steady-state kinetic constants for three yeast… CONTINUE READING