[Bradycardia after beginning therapy with metoprolol and paroxetine].


Because of their low incidence of adverse effects SSRI are prescribed more and more frequently in patients with depressive disorders. SSRI inhibit different subsystems of cytochrome-P 450-oxydase. Especially during co-administration of SSRI with antipsychotic and antiarrhythmic drugs pharmacokinetic interactions have to be observed carefully. In this presentation a case of bradycardia after co-administration of paroxetine and metoprolol is reported. Drug history and a careful drug monitoring are necessary requirements to avoid serious adverse effects.

Cite this paper

@article{Koenig1996BradycardiaAB, title={[Bradycardia after beginning therapy with metoprolol and paroxetine].}, author={Fritjoff Koenig and Matthieu Haefele and Barbara Hauger and Matthias L{\"{o}ble and Stephanie W{\"{o}ssner and Manfred Wolfersdorf}, journal={Psychiatrische Praxis}, year={1996}, volume={23 5}, pages={244-5} }