Bracken fern-induced malignant tumors in rats: absence of mutations in p53, H-ras and K-ras and no microsatellite instability.

@article{Freitas2002BrackenFM,
  title={Bracken fern-induced malignant tumors in rats: absence of mutations in p53, H-ras and K-ras and no microsatellite instability.},
  author={Renata Germano Borges de Oliveira Nascimento Freitas and Geraldo Brasileiro-Filho and Marcelo Eust{\'a}quio Silva and S{\'e}rgio D. Junho Pena},
  journal={Mutation research},
  year={2002},
  volume={499 2},
  pages={189-96}
}
Bracken fern (genus Pteridium) has been shown to induce tumors in domestic and experimental animals. Epidemiological studies have also shown an association between human exposure to bracken toxins and increased risk for the development of upper gastrointestinal tract tumors. Our aim in this study was to investigate possible genomic alterations in bracken fern-induced tumors of experimental animals searching for molecular markers that might be used for human epidemiological studies. Using human… CONTINUE READING
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