Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.

  title={Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.},
  author={Suzanne Carreira and Timothy J Dexter and Ugur Yavuzer and David J. Easty and C. R. Goding},
  journal={Molecular and cellular biology},
  volume={18 9},
Previous work has demonstrated that two key melanocyte-specific elements termed the MSEu and MSEi play critical roles in the expression of the melanocyte-specific tyrosinase-related protein 1 (TRP-1) promoter. Both the MSEu and MSEi, located at position -237 and at the initiator, respectively, bind a melanocyte-specific factor termed MSF but are also recognized by a previously uncharacterized repressor, since mutations affecting either of these elements result in strong up-regulation of TRP-1… CONTINUE READING

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