Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution.

@article{Hotta2008BrachyurydownstreamGS,
  title={Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution.},
  author={Kohji Hotta and Hiroki Takahashi and Noriyuki Satoh and Takashi Gojobori},
  journal={Evolution & development},
  year={2008},
  volume={10 1},
  pages={37-51}
}
In vertebrates, Brachyury, a T-box transcription factor gene, seems to have a dual role in the differentiation of axial midline mesoderm cells into notochord and gastrulation cell movements regulated by non-canonical Wnt/planar cell polarity (Wnt/PCP) signaling. To understand the function of Brachyury-downstream genes in chordate embryos, from a series of our survey on differential expression, including subtractive hybridization, dot-blot assays, EST sequences and the expression patterns in… CONTINUE READING
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