Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

@inproceedings{Faial2015BrachyuryAS,
  title={Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells},
  author={Tiago Faial and Andreia S Bernardo and Sasha Mendjan and Evangelia Diamanti and Daniel Ortmann and George E. Gentsch and Victoria L. Mascetti and Matthew W. Trotter and James C Smith and Roger A. Pedersen},
  booktitle={Development},
  year={2015}
}
The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates. Despite its wide use and importance in stem cell and developmental biology, its functional genomic targets in human cells are largely unknown. Here, we use differentiating human embryonic stem cells to study the role of BRA in activin A-induced endoderm and BMP4-induced mesoderm progenitors. We show that BRA has distinct genome-wide binding landscapes in these two… CONTINUE READING
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